This topic came up recently in another thread here. We have ground the mains "down" on 350 cranks to use them in small journal blocks fairly often. As long as one doesn't "push" the engine hard (over 6,500, maybe 450 HP), it should "live" just fine. Lots more low-end torque. Plenty of "high-end". If you want more than 350 HP, I'd use a forged crank. For a milder build the nodular unit seems to be fine.
I wouldn't advise using a 3.75" stroke with small mains.