What kind of truck are you talking about? This is definitely not going to be a daily driver right?
The first thing I thought when I heard 377 is that it's not the greatest motor for a truck, you'd be better off sticking with the stock 400 or 406 so you can take advantage of the torque. YOu can spin that motor up to 6000 without problems. Generally destroking is only done when you have to do it and its done for a light vehicle that spins really high RPMs (probably 7000+).
What are your goals with this truck, what do you want to do with it? We need more info.