My 69 pickup once had a 383 with Dart Iron Eagle heads (2.02/1.60), 9.3:1 compression, and an old skool Crane Energizer 266 cam at 266/266, 210/210, .440", .440". Manifold was a low rise Edelbrock 2101, although today I'd use a more modern Weiand Street Warrior. Carb was a 600 CFM Edelbrock. Even with a 3.08 axle, that thing would just shred the tires! Torque was just insane from right off idle, and the engine would rev to almost 5000, although HP probably peaked at 4500. Almost forgot -- I used a Hughes 2000 stall converter on the TH-350 trans. Not sure I'd do that today, because it slipped 100-150 RPM more than stock at 60 MPH. And since the long stroke of a 383 will raise the actual stall speed of a stock converter, that's probably all you need with a small cam like I used.
By the way, SCAT makes an I-beam rod with 7/16" cap screws (not bolt/nut) that will clear a lot of cams. Best way to check is with a flashlight and .060" feeler gauge. And you can't just check one cylinder, although I think there are only 2 (or 4?) that have the potential for trouble. Wish I could remember the numbers!
Also, be sure to search this site and others for how-to articles on relieving the block.