with 454 injectors you will wash out the rings and get a programmer that will reprogram the o2 sensors if not available you can get a programmer that omits one but this could have a negative efect on performance,its better to have functioning O2 sensors with a engine code than no sencors at all, plus an engine code doesn't always mean its not working,its just out of the computers factory acceptance spec. Hell advancing your timing can trip a code and engine light.
454 injectors put out way too much fuel. i tried a 454 tbi system on a 327 and all i got was a trashed engine, but you might try a bigger throttle body with say 60# injectors and go frome there but at this point you WILL NEED a programmer ir your computer will be pissed at you. Also look into after market Throttle bodies,if you think your selection on carbs are good on a v8,there are soooo many different throttle bodies ou there and you get to pick your injectors and air flow alowance and on and on and... you get the pic.