550 hp from a 454 is as mild as 420 hp from a 350. the heads you are talking about will support 600 plus hp.the short block just needs the CR and camshaft to match the power you want to extract from the heads. 396 to 496 doesnt matter it can be done.The bigger engine wont have to rev as high. I would never want a small bore long stroke for a race car,bigger bore engines make more power from the same heads.
If you want to squeeze more torque and fuel economy,or build lower power boat motor,or 4x4 engine then thats when a long stroke small bore might be the answer
If you do not have a big bore block and want one,sell what you have and build a 540 around 335 heads.a very mild 540 will make 650 hp and 700 pounds torque. up to 900 hp 598s that are pump gas friendly,,,costs a lot though.
figure your budget first