The 8.5 S-10 should have an Auburn-style cone limited slip if I recall correctly.
And there are TONS of us Impala SS guys putting 425 and more to our 8.5s; even using 383s, T56s, and 4.56 gears with DOT slicks. That's a lot of shock load. Properly set it up, it should handle a lighter Nova with no problem. The later 8.5s have 30-spline axles. Go for a ZR2 truck and get the disc brakes, too.