Rules pretty much go out the window for sure.
It also depends on how confident you are with what your doing.
I generally clear coat my base color when possiable. This provides a solvent resistant barrier for future paint work against bleeds and color mix issues,changes,mistakes.
I will shoot a coat of binder over something if it's going to sit awhile and just scuff it with a gray pad and continue on with the work later. This gives me a scratch for paint as well as a cover coat over light AB work so's it doesen't screw it up from scuffing directly on it.You can always apply some adhesion promoter like Dupont 222 if your in doubt.
This is not the "average" paint work and no way would I do a complete panel or vehicle for that matter "out" of it's window.