The key is correct ignition timing curve for the cam.
And not allowing the motor to idle at a low rpm while first cold.
Get it started and get the rpm to 2000+ rpm and hold it till some heat gets into
the manifold. if you think you can idle it low like a EFI motor when cold
you are going to go thru a lot of spark plugs.
Give it plenty of idle rpm when cold. Give it time to "warm up"
Correct the timing curve with plenty of initial base timing.
20-24deg base ,,34-36 at max mech advance
10-15deg of vacuum advance for part throttle cruise
the stock out of the box timing curve is never right.
Cammed up motors want a lot more initial base idle timing than stock.
Get a 750 eddy or 750 holley.