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For mileage you want the highest compression you can run with whatever cam you're looking at- but you also need to use a cam with low duration (which lends itself to lower compression).
If I were in your shoes, with those heads and a 383 I would go with a 10:1 compression and a cam in the 215º range with all the lift you can get (hyd roller with 1.6 rockers).
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