I had ran 9.5:1 cr with that cam that size in a sbc 350cid with stock iron heads in a 4000 lb truck with a 3.08 gear and auto trans. Took 93 octane.
You should ok with an extra 0.5:1 since the heads are aluminum and are fast burn heads (need less total timing). and you have more gears.
I predict mpg should be the same on the highway, but 2 mpg less around town due to the size of the cam.