Heeeeeeeeey Vegadeath, it can and has been done many many times. Guy here closed to me put a mid engine 350 in a Toyota, looks cool, lot of work though. Seen a 350 mid engine in a Izuzu too, was on the cover of Mini Truckin in the early 90's, was a deep plum purple with a nashty cromed out 350 in the bed.
That was cool trix for alot of mini truckers and alot of fantasy cars too. Just shorter driveshaft, some run front wheel drive engines in the rear from caddies. They just modify it a tad, just think volkswagen and you'll do fine, just remember, if you do use a front wheel drive car engine/trans, the stearing wont work very well so don't try it.