Yes, you would want to richen the main fuel circuit jets to prevent detonation. Detonation is usually not much of an issue on NA engines as long as CR and timing are right on, but a lean condition will certainly help the detonation process. By adding more fuel to the combustion process you move lower than stoich so there is some unburned fuel. This fuel cools and slows the combustion process to insure a uniform flame travel. When the AFR is lean the combustion heat is greater. This can cause hot spots and uncontrolled, sporatic combustion......or detonation.
BTW, AV can be run in an engine with no issues. Most plane engines are typical turbocharged gasoline engines.