Well I am no chemist or any of that stuff to brag about, but I do have a lot of experience with gasoline and running different octanes in engines. Running a gasoline with a severely higher octane than the engine requires will adversely affect the engines performance as it wont burn effectively, without doing major tuning to use that octane. Ill stack my experience over lab theories any day. The only advantage to running any fuel that is extremely higher in octane than the engine requires is that the engine may run nominally cooler, simply because the combustion isnt complete.
There are also other considerations like specific gravity of fuels, and btu out put to tend with. For instance, AV Gas generally weighs 1/2 lb to the gallon less than does standard pump gas of the same octane, requiring larger jetting.