Cylinder filling is the key.
Poor flowing heads prefer a tighter LSA. Exhaust scavenging from overlap helps the intake pull in more cylinder charge. Therefore, helping the intake port flow more.
Carbs prefer a tighter LSA. A carb needs more signal from the engine to deliver the intake change and exhaust scavenging increase the signal. An efi system can deliver fuel no matter what.
Not all efi's use manifold pressure to determine the amount of fuel required. Therefore, using wider LSA to increase vacuum for a MAP sensor is not the only reason to do so. EFI just doesn't need a lot of signal (air flow) from the engine to deliver fuel.
Rod/stroke ratio also effects the amount of LSA required. The location of the piston in the bore relative to the crank angle and valve timing can make big changes. Typically higher ratios prefer tighter LSA.