Here's a link to a Stude on a S-10 chassis w/ 4 link rear end creating an all wheel drive and 4 wheel independant suspension and a Caddy mill pushing thru a 4L80 into a jag rear end.
Now, an open wheel car would look a bit goofy with the stock Chevy setup out front but a full bodied car would hide it a bit.
Me? I'm going the 4x4 route for a Studebaker Conestoga wagon SUV and am looking for a longbed s-10 chassis to match my car's wheelbase.
Good luck with your project!