If you go 1:1 on a 350 it would produce 15.3 #'s of boost. On a 350 with only 8.5:1 static cr - with 14#'s of boost, that's going to raise your effective cr to 16.6:1. 15+ #'s of boost with a roots type blower is a lot for the street, can your motor hold that?
I have an 8-71 on a 383 with two BG 750 BC's on the street, it's very streetable, if not a little brutal. I opened up all eight primary idle air bleeds to help idle quality, and jetted it down two numbers on both sides, other than that, nothing.