I have run dual quads on almost everything I've ever owned, even my daily driven work truck had a warmed over 440 with a tunnel ram.
I found that certain carbs worked in certain conditions, and the tuning made all the difference. I ran two Holley 450 carbs on the work truck in the picture, it ran better than any single 4bbl I know of, cold starts, driveability, everything was pretty damned good.
The keys to MY tuning were using stock springs in the distributor for the advance, running 36-38 degrees total timing, and no vacuum advance lines were hooked up. I never had any troubles whatsoever.
I ran over a dozen small block Chevs with tunnel rams, and- with the exception of my two present cars, had most of my street cars I've owned with 2X4bbls for the last 15 years.
It's the combination you need- parts combination and tuning combination, and once you get it you won't go back, IMO...?