I would put on a early 70s q-jet carb. Something with little or no emissions crap on it. If you can find a 1 ton with a 350 in it or something, that carb would be awesome. A 1 ton would have "heavy duty emissions" (which didn't get all that emissions crap).
My 78 suburban had a 6800# GVWR which meant it qualified for heavy duty emissions. The carb on it (although it was a 454) had one vac line going to the distributor, one to the PCV valve, one to the air cleaner (two if you count the breather tube from valve cover to the breather) and then a short one that went to the choke, which was attached to the carb so it was like a 2" section of hose, almost not even worth mentioning.
It was very simple. It really wouldn't need any vacuum lines at all to run well but currently i do have the distributor and PCV valve hooked up.