No. Actually better, smoother running motor. More responsive. Plus you get to tune a slightly rich condition out of your motor by fine
tuning the mixture screws.
The 460 in my truck loves it. Runs like crap if I try to run it on ported.
Just listen for detonation though. It'll sound like a slight knocking at idle. Mine does but goes away when it warms up.If so pull your timing back a couple degrees. Bad detonation sounds like rocks in a tin can. Real hard on pistons.