Having never owned or driven a car with a blower on it, the only thing I can think of is it getting dirty real quick. Carb cleaner and a filter-cap may end up being your best friends on a trip like that.
On a side note, I wonder if a blower could force a bug through a filter, fry him instantly in the chamber and shoot him out the tailpipe?
Nothin' quite like charred bug on the windshield of the guy behind you. Now that has to blow.