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Some of the cheaper 2k's and most of the old 1k primers are bad about sucking up base paint requiring more coats is one reason sealer's came about.
Also allows you the option of tinting for a color closer to the base if the 2K is off some for what you need.
The better 2k's are good to go and most use sealer as "feel good" or just in case their sanding skill's are lacking.
I personally have not used epoxy as a sealer coat so I can't comment on that.
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