When you look at the shape of the S-10 body, as compared to the early trucks/cars, there is considerable difference. The earlier vehicles were narrower in the front than in the rear. That allowed the radiator to appear to follow the body shape, without the fenders attached. The frames were also narrower in the front, in a similar manor. There was also very little stuff in the engine compartment that cluttered things up. Since the S-10 frame is so wide, to accomodate the suspension, it would likely look out of place sticking out in the open.
Although you could obviously make the vehicle operable, the job of making it look like something interesting would be alot of work.