I had a stock 350 two bolt in my F-1 until last winter. I built it as a stroker 383 using Vortec heads, Edelbrock RPM intake,Holley 670 cfm Street Avenger, CompCams XE268H cam, lifters and springs and 1.5:1 rockers. Compression is 10.2 and hyperutectic double eyebrow pistons. Rods are 5.7". Using a 2000 stall in front of TH350. 1 5/8" headers into 2.5" collectors and final exhaust with crossover. I use a mag lite distributor and MSD 6AL system (not necessary with this combination. This is basically the 425 hp Chevy 350 builds that all the magazines put on the dino except it is 38 cu inch bigger and a lot more torque. The longer stroke gives the motor something like 450 ft lbs at 2000 rpm and would do that with a two barrel and a crappy cam and intake.
The engine wants to idle at about 850 rpm and is definitely a hot sounding combination. The motor has massive low rpm torque for street driving, gets bad mileage (becasue of the cam). At about 3500 rpm it begins building what I will call flash power which is linear to a point I have not tested. It feels a jet take off surge and the rpm's build so fast it is scary. I will say it is a lot more motor than is necessary for a spirited ride where you want a good passing gear. I would be happy with a smaller cam really but this one really performs without bad manners except for the high idle. The stroker build is the real sleeper, you get the low rpm torque which is what you want in a pickup.
The Vortec heads are plenty. They will flow well to about 4500 rpm without modification. If you want to race and win, you would want to spend $1200 or so for bigger heads, but for street, you can't beat vortec for price/performance.