Had a setup like this in a 89 S-10 years ago.
Edelbrock RPM heads
Nitrous HP cam
Dual plane intake
700R Trans 2500stall
9" rear with 3:50gear.
With all the torque you'll be making a 3:42 gear is plenty.
The Edelbrock heads will net you 10.71compression. Fine on 93oct.
My truck went 11.5-11.6's on motor and mid 10's at 132mph on 150hp.
Good luck with the build. Don't get into bigger cam/head/stall/gear is better and you'll be just fine.