If you are talking about rotating assembly clearances, then the connecting rod nuts(if thru-bolt) or bolt head(capscrew type rod) may have clearance problems with the oil pan rail area of the block.....easy to fix, slight 1/16-1/8" groove ground to clear the rod in the oil pan rail, and the stroker oil pan with clearance flats stamped in the pan rail.
you will also have to put similar notches at the bottoms of the cylinder barrels, near the can tunnel, depending on which connecting rods are used.
You'll need to do a trial assembly, one cylinder at a time. to find all the locations to grind. SBC strokers have to go through the same process.
This pan image will give you a good idea what this is, block needs to look something like that at the oil pan rail.
Hot Rod mag article that will help you a lot.