I personally would keep it silky smooth. You can use a cam that has some lope to it, but in my opinion, once you've gotten lope in a 5000-lb pickup, you've gone about two steps past something you'll enjoy driving on the street.
If you want a tiny bit of lope, go with a 214/224 cam or similar on a 110 LSA. You'll need about a 3200-stall converter and 4.10 gears to make that heavy truck get moving. Put it all under Vortec heads and you should expect about 375-400 hp with good headers, an RPM-type intake, and a Qjet or 750cfm carb. Make sure you build the bottom end to be capable of spinning to about 6000 rpm so you can get to that powerband.