454 Hudson
what kind of comression does your 454 have?
Are you anticipating an aftermarket intake? cam? carburetion? ignition?
If you can find headers to fit your setup, thats always a good place to start. Not real familiar with the old Hudsons, so you might want to do some careful measuring of the engine bay, frame width, and the width length, and height of your engine.
You may well have to use a header thats designed for your engine going into a tight chassis like a Nova or Camaro.
Things to consider are your steering linkages, master cylinder, heater box, things like that.
Are you going to run a stick or automatic trans? An automatic may well be the easier way to swap.
What about your radiator?