Hi folks, first post for me but given I have run a 454 small block for the past 4 years and freshen it with new details almost every year I thought I could add a little value to this thread.
The only way you are really going to get super big cubes with durabiity our of a small block is with the aftermarket blocks out there. A few details make these blocks much better than a standard 400 core. First the pan rails are spread to give clearance for up to a 4.250 stroke crank, which you need for displacement over 454, I run 4.125. Next the deckheight is taller, up to 9.5, so you can get a loooong rod in there and keep the pin height down. Next the oiling system is priority main. Next bore sizing, depending on brand can be up to 4.25 or so. Next the cam tunnel is raised so clearance with the big cranks is not an issue, plus most come with big block bearing sizes for the cam as well so running .700 lift like I do on the street is no problem. Strength is also far superior with an aftermarket block, basically throw whatever you have the balls to throw at it for power and it will take it. Finally weight, my bare aluminum block weighs 98 lbs, nearly 100 less than a standard aftermarket cast iron small block.
There are a ton of good reasons to build a big small block and a ton of good reasons not to. I did it just to be different and beat up on the big blocks at the track. If I had to do it over again I'd do a Brodix aluminum big block with 18 degree heads and a turbo.
A reason though to do it is with good heads and around 11:1 compression you'll smack the chassis dyno silly with 500 ft lbs of torque at 3000 RPM and spin up around 550 to 600 HP on the top, with pump gas. Then you always have the nitrous to pelt those pesky turbo big blocks.
Building a motor like this and living with it year to year does take maintenance. I typically will tear it down every year for inspection. Of course my buddies that run serious big blocks do that as well. Making big HP has those downsides.
To do a build up like this the two blocks I would consider would either be the Dart or the Brodix.