The biggest diffrence is in the sides. Most oem use plastic sides for aluminum while with brass they (often) have no plastic.
Plastic sides can and do crack over time. The plastic also insulates vs sheding heat like metal sides can.
Here is my best recent comparison.
This 91 geo had a brass radiatior factory with the stock fan.
View attachment 629238
I replaced it with a slightly taller and larger capacity aftermarket radiatior using a new stock fan.
View attachment 629239
The aluminum radiatior is noticably lighter. I want to say 2 to 3 pounds.
It holds .6 more quarts. Which does not sound like much until you consider the normal capacity is 4.1 quarts(yes tiny engine). So for about the same weight(of the added fluid) around a pound lighter overall. I have a 4.7 quart system. That is a 14.6% increase just from running aluminum.
The cost of a fully aluminum radiatiors have come down significantly. Actually on a few silveradios I have found direct bolt in full aluminum for less then the cost of a oem replacment with plastic sides.
Full aluminum is often less cost then full brass and the chance of you finding an aluminum replacment in 5 years is much higher then finding the same brass replacment for a similar price point.