Nice post Eagle...jives with my experience.
Avoid breathing all paint fumes especially isocyanate's.
I developed a DIY, cheap, homemade, easy to don, supplied air respirator to reduce my inhalation of paint fumes (may not work safely for others, don't try this at home). I use a high end respirator with organic vapor cartridge such as 3M 5201 or better ( about 30 USD). The respirator will not remove all of the isocyanate's or other VOC's, especially when the cartridge becomes saturated.
I purchased two second hand nebulizers for cheap. I placed both nebulizers in a clean air environment. I ran small clear tubing from the nebulizers to my 3M respirator. The sum of the clean air from the nebulizers produces a positive pressure of clean air in my mask and I am sure I inhale less paint fumes than my friends who only use the respirator with no clean air. If I had rich friends they would buy an expensive bulky supplied air respirator system.