take the push rods out of #2 and #4, roll them on a formica counter to be sure they aren't bent, NO wobble allowed
swap #2 and #4 rods with rods from 2 other cylinders, problem still in 2 and 4, most likely the lifters
small-small chance for a (sticking-dirty lifter) cure without tearing it down, give it a dose of Marvel Mystery Oil or Wynn's, won't hurt and will clean the varnish out of the motor if you do have to replace the lifters
You need to fix the valve train first and now before addressing what maybe a timing issue,
Clarification? I meant (it's OK) to start it with 12 deg, then turn it back to 6 while it's idling so during the test drive the timing will come in later and less to test for detonation.
till the valve train is fixed, set it at? 8 so it starts easy