Nothing really, other then longer warm up time. It is very common on olds motors to do this for hot rod purposes. Be for warned that the aluminum blocker blocks you can buy tend to rattle a little. I blocked mine with a thin piece of sheet metal I placed in the turkey tray opening with some gasket sealer.
I lot of racers will fill it with molten aluminum, then they work it to be part of exhaust port, then heat risers are in the center 2 exhaust ports.