reverse rotation
jmhollis added in some good points that I failed to cover, mainly the oil pump.
Yes, the crank can run in either direction, as there are several different firing orders, that can be chieved with any engine, example is the 302/5.0 Fords which were built with two different firing orders, yet using the same crank throw design.
I am presuming that from your thread, you have a marine engine that you are thinking about putting into an automobile?
If this is the case, then its basically a matter of changing over to a conventional automotive cam, ignition, oil pump, and cooling system, and the intake setup as well. If this a popular engine, such as a SBC, BBC, SBF, or BBF, then vertually all the parts you will need to use it will be easily obtained.
As an afterthought, you will probably have to change oil pans as well, since marine oil pans are generally not condusive to putting into an auto, due to the design.
Most boats that have a reverse rotation engine will generally have them on the port side, and the starboard engine which will have typical rotation, will drive all the accessories such as your charging system, making it simpler to use standard automotive alternators and such.
Marine engines will have a different cooling system on them than an automobile. You will have a water jacketed exhaust manifold which is fed from the engine discharge, and will be exited out the rear of the boat. The coolant for such systems, the pump draws its water directly from the body of water your craft floats in.
As was also noted by jmhollis, if you are anticipating running a reverse rotation engine in an automobile, you will step into a whole new field of problems, such as he mentioned with the electrical charging system, cooling, auxilary drives etc. Then there is also the matter of setting up a rearend to transfer your power.
Years ago, a few brave souls tried reverse rotation engines in Stock Car racing, and what it amounted to was a lot of money spent for absolutely no gain whatsoever.